Hsp90相关论文
嫩度是评价肉质的重要指标,也是影响消费的因素之一,宰后成熟是嫩度改善的主要方法,钙激活酶、细胞凋亡酶等内源酶对肌原纤维蛋白......
研究背景:分子伴侣热休克蛋白90（Heat shock protein 90,Hsp90）是真核细胞在生理和应激条件下维持蛋白稳态的关键调节因子,涉及蛋白......
[目的]HSP90是热休克蛋白家族的成员之一,在昆虫的抗逆性和变态发育中发挥重要作用,已有研究表明HSP90能够促进家蚕核型多角体病毒......
目的 验证马归液对内毒素致膀胱上皮细胞中HER2磷酸化及HSP90表达的干预作用.方法 采用免疫荧光技术、Western Blotting实验,验证......
热激蛋白（Heat Stress Proteins, HSPs）又称热休克蛋白（Heat Shock Protein, HSPs）,是机体受到外界的一些环境条件刺激如：氧气缺乏、温......
学位
分子伴侣Hsp90与其共分子伴侣Cdc37在真核细胞中通过形成Hsp90/Cdc37复合物发挥指导激酶客户蛋白正确折叠的作用,研究发现,这一复......
目的食管鳞癌是一种恶性肿瘤,缺乏明确的药物分子靶点。Hsp90作为一种分子伴侣,在多种癌症中过表达,是预后不良的标志物。研究表明......
目的:HSP90α是HSP90的一种亚型,位于胞质内,由730个氨基酸组成。HSP90AA1是HSP90α的功能基因。拟通过质粒转染对HSP90AA1进行过......
背景:随着世界人口老龄化进程的到来,神经退行性疾病的发病率越来越高,已经成为增加人类（尤其是老年人）死亡的重要原因。氧化应激被......
背景 肝细胞癌是全球第六大常见癌症,早期诊断主要依靠血清学检查,随着热休克蛋白90(heat shock protein 90,HSP90)对于肝细胞癌分......
前言心脏纤维化（Cardiac Fibrosis,CF）是心脏组织中的瘢痕形成过程,其特征是I、III型胶原沉积增加,心脏成纤维细胞激活并分化为具有......
昆虫属于小型变温动物,温度胁迫能影响昆虫的生存、种群动态和分布。热激蛋白（Heat shock protein,HSP）是受温度胁迫后响应最为显著......
背景糖尿病时,心肌微血管损伤往往发生在大血管及心肌细胞损伤之前,是糖尿病心肌结构与功能障碍的重要始发因素之一,也是导致糖尿......
研究目的:肝细胞癌（Hepatocellular carcinoma,HCC）是全球第六大恶性肿瘤,死亡率排在第三位,给人民健康造成极大威胁[1]。射频消融（Ra......
研究目的:本研究旨在围绕前期研究中发现的、频发于胶质母细胞瘤的FGFR3-TACC3融合基因,重点探索该融合基因对应融合蛋白的翻译后......
昆虫属于变温动物,其生命活动受环境条件的制约,极端的环境因子影响其正常生活,同时也威胁昆虫种和个体的生命维持.滞育是由神经激......
The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial
The protective effect of aspirin during exposure to heat stress in broiler chickens was investigated.We assayed the path......
本论文选择在我国分离得到的一株能典型产生麻痹性贝毒(PSP,Paralytic Shellfish Poison)的有毒赤潮甲藻塔玛亚历山大藻(Alexandri......
目的 探索Geldanamycin 敏化Gefitinib 对KRAS 突变型肺癌A549 细胞的抑制效果,评估联合用药在该疾病治疗中的可行性。方法 MTT 实......
目的 通过比较皮肤基底细胞癌组及正常组织中的HSP60 和HSP90 的表达水平，探索HSP60 和HSP90 在皮肤基底细胞癌中的表达及意义。方......
目的 Pulmonary fibrosis is a progressive disease with poor prognosis and treatment.It is characterized by lung fibroblas......
目的 Secreted Hsp90 alpha (sHsp90α) plays an important role in cell mortality and would healing,we hypothesized that sH......
目的 肝癌是异质性最强的肿瘤之一。不过,目前准确捕捉肿瘤异质性的形成节点几乎不可能；相对而言,针对可捕捉“薄弱点”的靶向策略......
目的 Epithelial to mesenchymal transition(EMT)is related to invasive andmetastatic during lung cancer development.Extrac......
目的 低剂量藤黄酸(GA)联合NaI131共同作用于耐药的NSCLC细胞株,检测细胞内HSP90、mtp53及MDM2蛋白及基因表达情况,验证GA对于NaI1......
Apigenin(4,5,7,-trihydroxyflavone) is a common non-mutagenic plant flavonoid widely distributed in vegetables and fruits......
Gastric cancer (GC) remains the fifth most common cancer worldwide.Heat shock protein 90 (HSP90) has become an attractiv......
Background & Aims: Hepatocellular carcinoma (HCC), one of the most common malignant human cancers worldwide, is identifi......
Identification of copy number variations associated lncRNAs analysis reveals IncRNA-PRAL promotes ap
Recurrent genome copy number aberrations are known to be a common feature of many cancers,including hepatocellular carci......
钩吻(Gelsemium elegans Benth.)为马钱科(Loganiaceae)胡蔓藤属(Gelsemium)植物.钩吻全草有毒，民间一直以外用为主，治疗皮肤病.吲哚......
3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting
OBJECTIVE To investigate 3-0-(Z)-coumaroyloleanolic acid (3-COA), an active ingredient of oleanolic acid in the TAIWANG ......
HSP90 既是细胞应激反应的生物标志物，也是细胞的内源性保护蛋白，发挥着分子伴侣的作用.HSP90 调控的客户蛋白有很多，包括EGFR、Met、......
Aim To explore the effect of Neiyixiao on hypothalamic-pituitary-ovarian axis in rats model of endometriosis (EMS).Metho......
Background: Epithelial to mesenchymal transition (EMT) is related to invasive and metastatic during lung cancer developm......
会议
Background: Pulmonary fibrosis is a progressive disease with poor prognosis and treatment.It is characterized by lung fi......
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract.Oncogenic KIT or PDGFRA r......
目的 探讨姜黄素衍生物C212的抗肿瘤活性及其作用机制.方法 应用MTT法检测C212及Cur对K562、HL-60、SW620、HT-29、HCT-116、MCF-7......
会议
分子伴侣HSP90在多种癌症中功能异常,使得HSP90成为癌症治疗中一个很有前途的靶点.我们从基于片段的设计出发,设计合成了一类包含4......
P239, a recombinant HEV capsid protein covering aa368-606 of HEV ORF2, is the mimic form of the virion.In our research, ......
Hsp90 is a molecular chaperone responsible for facilitating maturation of client proteins include oncogenic tyrosine kin......
Ligand Fishing and In situ Imaging Using Heat Shock Protein 90 Coated Fluorescent Mesoporous Silica-
Ligand fishing by the targeted protein immobilized onto nanospheres surface has been demonstrated a high-efficient techn......
苯安莎霉素为一类十九元大环内酰胺天然产物，具有显著的热休克蛋白90(Hsp90)抑制活性，表现出很好的抗肿瘤药物发展前景。其结构一般......
...
